Precise control of tiny liquid volumes is essential for modern biochemical analysis, yet reliably dispensing nanoliter-scale droplets remains technically challenging. This study presents a light-controlled droplet dispensing strategy that enables highly accurate generation of tunable nanoliter droplets on a microfluidic chip. By combining optoelectrowetting with dynamically designed light patterns, the system guides droplets to deform, shrink, and detach in a controlled manner. The approach achieves exceptional volume consistency across a wide range of droplet sizes and supports stable formation of uniform droplet arrays. Beyond technical precision, the work demonstrates that light-driven droplet control can reliably support small-scale biochemical reactions, offering a powerful alternative to conventional liquid-handling methods.
Projecting Light to Dispense Liquids: A New Route to Ultra-Precise Microdroplets
