Making Invisible Cancers Visible: Study Suggests a New Route to Turn 'Cold' Tumors 'Hot'

One of the biggest challenges in cancer immunotherapy may not be that immune cells are too weak, but that some tumors give them too little to see. New research from Dana-Farber Cancer Institute scientists reveals how cancers carrying mutations in the p53 tumor-suppressor protein can hide those mutations from T cells and suggests a therapeutic strategy as a countermeasure: Change what the cancer displays on its surface so the immune system can recognize the tumor.